腸の科学情報

                       腸内細菌情報2006年


12月分

Otieno DOら(オーストラリア):Int J Food Microbiol, Dec 14, 2006. Isoflavone phytoestrogen degradation in fermented soymil with selected B-glucosidase producing L. acidophilus strains during storage at different tempateratures.

Seregeev INら(USA):Life Sci 80: 245-53, 2006. Polymethoxylated flavones induce Ca++-mediatedted apoptosis in breast cancer cells.

Yuan JMら(USA):Int J Cancer, Dec 5, 2006. Urinary biomarkers of tea polyphenols and risk of colorectal cancer in the Shanghai Cohort study.

Yazawa Kら(京大):FEBS Lett 580: 6623-28, 2006. Distinct mechanisms underlei distinct polyphenol-indused neuroprotection.

Unenisi Gら(京都府大):Am J Primatol, Dec 19, 2006. Molecular analysis of the intestinal microbiota of chimpazees in the wild and in cavity.

Vinderola Gら(アルゼンチン):Int J Food Microbiol Dec 19, 2006. Mucosal immunomodulation by the non-bacterial fraction of milk fermented by Lactobacillus helveticus R389.

Posserud Iら(スエーデン):Gut, Dec 5, 2006. Small intestinal bacterial overgrowth in patients with irritable bowel syndrome.
小腸における細菌の異常増殖はIBSにあまり関係しない。

Zhang Mら(中国):J
Clinical Microbiol, Dec 6, 2006. Structural shifts of mucosa-associated Lactobacilli and Clostridium leptum subgroup in patients with ulcerative colitis.

Benton Dら(UK):Eur J Clin Nutr, Dec 6, 2006. Impact of consuming a milk containing a probiotic on mood and cognition.
ヨーグルトはムードを良くするが、ムード(気分)の改善は便通の増加と無関係だ。

Ghosh SKら(USA):Blood Cells Mol Dis 38:57-65, 2007. Short discontinuous exposure to butyrate effectively latently EBV-ifected lynphoma cells to nucleaside analogue antiviral agents.

Lan Aら(フランス):Apoptosis, Dec 29, 2006. Acidic entracellur pH shifts colorectal cancer cell death from apoptosis to necrosis upon exposure to propionate and acetate, major end-products of the human probiotic propionibacteria.
SCFAはpH6.0−7.5でアポトーシスを引き起こす。

Duncan SHら(UK):Appl Environ Microbiol, Dec 22, 2006. Reduced dietary intake of carbohydrate, by obese subjects, results in decreased concentrations of butyrate and butyrate-producing bacteria in feces.
酪酸濃度はその産生菌のRoseburia spp と Eubacterium rectaleの存在と関連する。糖摂取の現象は酪酸の現象、上記の細菌とビフィズス菌の減少がみられる。

Li CJら(USA):Funct Integr Genomics, Dec 21, 2006. Pathway analysis identifies perturbation of genetic networks induced by butyrate in bovine kidney epithelial cell line.

Akare Sら(USA):Int J Cancer 119:2958-69, 2006. Ursodeoxycholic acid modulates histone acetyl and induces differentiation and senescence.
UDCAは染色他を修飾する。ヒストン低アセチル化に基づく。結腸がん細胞の文化と老衰をもたらす。

Chen Hら(中国):Nutr J, Dec2, 2006. Antioxidant activity and hepatoprotective potential of agaro-oligosaccharides in vitro and in vivo.
分子量500〜2500の寒天オリゴ糖は肝細胞のオキシダントの消去に働く。

Winkler Jら(オーストラリア):Dig Dis Sci, Dec 14, 2006. Fructo-oligosaccharide reduces iflammation in a dextran sodium sulphate mouse model of colitis.
FOSはクリプトにおける損傷の回復を早める。遠位部結腸の病的活性を低下、損傷を抑える。

Jergens AEら(USA):Gut, Dec 4, 2006. Helicobacter bilis triggers persitent immune reactivity to antigens derived from the commensal bacteria in gnotobiotic C3H/HeN mice.
H. bilisはからだの反応をかえる。常在細菌の過敏症免疫を増進させる。

Foley KFら(USA):Am J Physiol Gastrointestinal Liver Physiol, Dec 14, 2006. IFN-γ nad TNF-αdecrease serotonin transporter function and ezpression in intestinal epithelial cells.
粘膜のセロトニン運搬の発現は腸炎で低下している。潰瘍性大腸炎でも低下。セロトニン運搬のmRNAとタンパク質の低下がある。



11月分


Nettleton JAら(ノルウエー):J Nutr 136:3039-45, 2006. Dietary flavonoids and flabonoid-rich foods are not associated with risk of type 2 diabetes in postmenoposal women.
追跡調査の結果、フラボノイドは糖尿病に抑制的でない。アルコール飲料ではノン・フラボ成分に糖尿病抑制がみられる。

Thanos Jら(カナダ):Cancer Cuases Control 17:1253-61, 2006. Adolescent dietary phytoestrogen intake and breast cancer risk(Canada).
植物性エストロゲン摂取は乳ガンの危険性を抑える。

Penza Mら(イタリア):Endocrinology 147:5740-51, 2006. Genistein effects adipose tissue tissue deposition in dose-dependent and gender-specic manner.

Magne Fら(フランス):FEMS Microbiol Ecol 59:563-71, 2006. A longtudinal study of infant faecal microbiota during weaning.

Tamura Mら(食総研):Anaerobe Nov 16, 2006. Isolation of an isoflavone- metabolizing Clostridium-like bacterium, strain TM-40, from human faeces.

Manjanatha MGら(USA):Carcinogenesis 27:2555-64, 2006. Dietary effects of soy isoflavones daidzein and genistedin on 7,12-dimethylbenz[a]anthracene-induced mammary mutagenesis and carcinogenesis in ovariectomized Big Blue(R) transgenenic rats.
イソフラボン投与はDMBA誘起変異をとくに変えない。

Cotterchio Mら(カナダ):J Nutr 136:3046-53, 2006. Dietary phytoestrogen intake is associated with reduced colorectal cancer risk. 1997ー2000の疫学調査。20−74歳、オンタリオ。



Chirakkal Hら(UK):Oncogene 25:7192-200, 2006. Upregulation of BAK by butyrate in the colon is associated with increased Sp3 binding.

Bengmark Sら(UK):Clin Nutr Nov 16, 2006. Bioecological control of inflammatory bowel disease. 腸炎は超内容の全部の交換がそうこすることがある。

Bikker Pら(オランダ):J Anim Sci 84:3337-45, 2006. The effect of dietary protein and fermentable carbohydrates levels growth performance and intestinal characteristics in healthy weaned piglets.

Wilfart Aら(フランス):J Anim Sci Nov 22, 2006. Sites of nutrient digestion in growing pigs: effect of dietary fiber.

Conte MPら(イタリア):Gut 55:1760-7, 2006. Gut-associated bacterial mkicrobiota in paediatric patients with inflammatory bowel diseas.
腸粘膜の好気性細菌はIBDで多いが、嫌気性細菌は少ない。とくにBact. vulgatus は少ない。

Smith Kら(カナダ):Semin Immunol Nov 20: 2006. Use of axenic animals in studying the adaptation of mammals to their commennsal intestinal microbiota.

Bjursell MKら(USA):J Biol Chem 281:36269-79, 2006. functional genomic and metabolic studies of the adaptation of a permanent adult human gut synbiont Bacteroides thetadiotaomicron, to the suckling period.



10月分


Penders Jら(オランダ):Gut oct 17, 2006. Gut microbiota composition and development of atopic manifestations in infancy: Yhe KOALA birth cohort study.
E. coliと湿疹が関係あり。C. difficileとアトピー性症候と関係ある。

Osman Nら:BMC Gastroenterol Oct 28, 2006. Bifidobacterium infantis strains with and without a combination of oligofructose and inulin(OFI) attenuate inflammation in DSS-induced colitis in rats.

Riordan SMら(オーストラリア):Curr Opin Gastroenterol 22:669-73, 2006. Bacterial overgrowth as a cause of irritable bowel syndrome.
irritable bowel syndromeはフローラの異常化をもたらし、症状を悪化する。

Zipfel Sら(ドイツ):Auton Neurosci 129:99-106, 2006. Gastrointestinal disturbances in eating: Clinical neurobiological aspects. 食欲不振は胃の空腹が遅れ、さらには便秘と関係する。

Maia MRら(UK):Antonie Van Leeuwenhoek Oct 28, 2006. Metabolism of polyunsaturated fatty acids and their toxicity to the microflora of the rumen.

Savino Fら(イタリア):Eur J Clin Nutr 60:304-10, 2006. Reduction of crying episodes owing to infantile colic: a randomized controlled study on the efficacy of a new infant formula. 新しい人工乳(ホエイ蛋白質水解物、オリゴ糖、β-パルミチン酸)は腹痛による泣きを減少。


Lee HCら(シンガポール):Res Microbiol 157:876-84, 2006. Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota.

Steiner Cら(ドイツ):Carcinogenesis Oct 26, 2006. Gensitein protects human mammary epithelial cells from benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide and 4-hydroxy-2-nonenal genotoxicity by modulating the glutathione/glutathione-S-transferase system.
ゲニステインは人乳房細胞のベンツピレンによるDNA損傷を抑える。これはGSTsに寄るベンツピレンの毒性低下に基づくようだ。

Al-Nakkash Lら(USA):J Nutr 136:2785-90, 2006. Dietary genistein stimulates anion secretion across females murine intestine.

Tsangalis Dら(オーストラリア):Eur J Clin Nutr Oct 4, 2006. Urinary excretion of equol by postmenopausal women consuming soymilk fermentation by probiotic bifidobacteria. Bif発酵豆乳は閉経婦人に明瞭なequol 産生者の増加につながらない。

Ventura Mら(イタリア):Antonie Van Leeuwenhoek Oct 28, 2006. Genomics as a means to understand bacterial phylogeny and ecological adoption: the case of bifidobacteria.


Hino Kら(林原生化学):Biosci Biotechnol Biochem 70:2481-7, 2006. Effect of dietary cycle nigerosylnigerose on intestinal functions in mice.


Park KBら(韓国):Production of yogurt with enhanced levels of γ-aminobutyric acid and valuable nutrients using lactic acid bacteria and germinated soybean extract.

Farzanfar A(イラン):Fems Immunol Med Microbiol 48:149-58, 2006. The use of probiotics in shrimp aquaculture.

Massi Mら(イタリア):World J Gastroenterol 12:5987-94, 2006. Effects of probiotic bacteria on gastrointestinal motility in guinea-pig isolated tissue.
Lactは回腸の収縮を高め、使用したプロバイオティクスは全て近位結腸を弛緩させる

D'Arienzo Rら(イタリア):Res Microbiol 157:891-7, 2006. Bacillus subtilis spores reduce subsceptibility to Citrobacter rodentium-mediated enteropathy in a mouse model.

Marzotto Mら(イタリア):Res Microbiol 157:857-66, 2006. Lactobacillus paracasei A survives gastrointestinal passage and affects the fecal microbiota of healthy infants. L. paracasei AはLactとBifの多様性に影響。

Yamano Tら(ネッスルJapan):Life Sci 79:1963-7, 2006. Effect of the probiotic strain Lactobacillus johnsonii strain La 1 on autonomic nerves and blood glucose in rats. La 1株は自律神経を介してグルコース代謝に影響。これは交感神経の抑制にもとづく。